Further, a significant reduction in the levels of various cytokines such as endoglin, endothelin-1, FGF-1, FGF-2, follistatin, IL-8, PLGF and VEGF-A was observed in the homogenates of HT-29 tumor xenografts obtained from mice treated with DOX in combination with fidarestat, which indicates that AR inhibition prevents DOX-induced inflammatory cytokines and chemokines in the tumor tissues and thereby reduce tumor growth (Table 1). This evidence concerns the gene EDN1 and neoplasm.