Consistent with our results, several antioxidants have been shown to decrease the expression of multidrug resistance conferring proteins such as P-glycoprotein (MDR1), MRP1 and ABCG2 and increase the sensitivity of chemotherapeutic agents not only towards colon cancer but also for lung and breast cancers39, 42–44. The gene discussed is ABCB1; the disease is malignant colon neoplasm.