Previous studies have indicated that a single nucleotide polymorphism in the IL-12B gene (SNP; rs3212227) was significantly associated with a risk of a wide range of autoimmune and inflammatory diseases, such as psoriasis17, type-1 diabetes18, asthma-severity phenotype in Caucasians19, Crohn’s disease20, and rheumatoid arthritis21. Here, IL12B is linked to asthma.