Treatment with the resveratrol (10–50 μM) activated chromatin-associated SIRT1 protein on the cIAP-2 promoter region, which resulted in a loss of NF-κB-regulated gene expression and consequently augmented the tumor necrosis factor α (TNFα)-induced apoptosis in human non-small-cell lung cancer cells53. The gene discussed is NFKB1; the disease is non-small cell lung carcinoma.