As showed in Fig. 6, the treatment of pre-osteoclasts with recombinant AREG had the similar effects of NSCLC-exosomes on the induction of EGFR phosphorylation causing an increase of RANKL that modulated MMP9 and TRAP expression and induced the typical phenotype of mature osteoclasts. The gene discussed is TNFSF11; the disease is non-small cell lung carcinoma.