As showed in Fig. 6, the treatment of pre-osteoclasts with recombinant AREG had the similar effects of NSCLC-exosomes on the induction of EGFR phosphorylation causing an increase of RANKL that modulated MMP9 and TRAP expression and induced the typical phenotype of mature osteoclasts. Here, EGFR is linked to non-small cell lung carcinoma.