Another study revealed a role of miR-197 as tumour suppressor in mediating apoptosis in multiple myeloma cells by targeting MCL115, while in non-small cell lung cancer it contributed, when down-regulated, to chemoresistance through the miR-197/CKS1B/STAT3-mediated PD-L1 network16. The gene discussed is CD274; the disease is non-small cell lung carcinoma.