HDAC6 and cancer: Notably, although bafilomycin A1 treatment could dramatically elevated the protein abundance of LC3B-II, a biomarker of autophagy, it did not lead to significant changes of HDAC6 protein level in various cancer cell lines including HCT116 (Figure 1F), DLD1 (Supplementary Figure 1D), and HeLa cells (Supplementary Figure 1E).