However, depletion of Cullin 3, but not Cullin 1, elevated the protein abundance of endogenous HDAC6 in multiple cancer cell lines including HT29 (Figure 2B-2C), HCT116 (Figure 2D-2E), PC3 (Supplementary Figure 2A-2B), and HeLa (Supplementary Figure 2C). The gene discussed is CUL1; the disease is cancer.