Importantly, we found that both MG132 and MLN4924 treatment stabilized HDAC6 at the endogenous level in multiple cancer cell lines including HT29 (Figure 1A-1B and Supplementary Figure 1A), HCT116 (Figure 1C-1D and Supplementary Figure 1B), and HeLa (Figure 1E). The gene discussed is HDAC6; the disease is cancer.