As shown in Table 1, we also investigated the correlation of HIF-2α expression with clinicopathological features in the pancreatic cancer patients and found that HIF-2α expression was significantly correlated with tumor differentiation (χ2=6.921, P=0.026), clinical stage (χ2=6.460, P=0.017), and lymph node metastasis (χ2=5.250, P=0.040). This evidence concerns the gene EPAS1 and familial pancreatic carcinoma.