ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: The biological role of ERα36 and its relationship with BCR-ABL in CML/ALL is not known, but we demonstrated for the first time that ERα36 is highly expressed in BCR-ABL+ leukemic cells, including BCR-ABL-T315I mutant cells, and abnormally localizes to cytoplasm and cell membrane of these cells, differing from full-length ERα66 (Figure 1).