PDPN and neoplasm: Prior studies determined that endogenous M-LECP are characterized by the following traits: 1) chemo-attraction to tumor [29,53] and inflamed sites [14,22]; 2) co-expression of LEC-specific markers such as Vegfr-3, Lyve-1 or Pdpn and myeloid markers such as CD11b, CD14 or CD68 [16,60]; 3) preferential integration into lymphatic [12,13,22] as opposed to blood vessels [12]; and 4) the ability to increase the density [13,24,32] and the function of lymphatic vessels [25].