Amongst the top-scoring proteins predicted to play a role in a three-way multimorbidity between asthma, eczema and rhinitis we identified interleukin receptors IL4R, IL21R and IL2RB. Both IL4R and IL21R are strongly related to the immune response, and are already known to be associated to asthma and rhinitis. This evidence concerns the gene IL21R and Eczematoid dermatitis.