It is known that both IL4 and IL13 are involved type 2 responses, in IgE production in asthma, rhinitis [52] and in eczema [53], as well as in the cellular inflammation of the three diseases [54] as well as in the regulation of the epithelial barrier function in the skin [55], the airways [56], and type 2 responses [57]. Here, IGHE is linked to rhinitis.