CCL2 and asthma: The highest-scoring candidate protein for comorbidity between asthma and eczema were C-X-C motif chemokine 14 (CXCL14), a known mediator in inflammatory processes, and myeloblastin (PRTN3), a matrix-degrading proteinase also related to asthma [88], and chemokine ligand CCL2, known to be upregulated by IL31, which in turn is one of the main inducers of skin pruritus in eczema [89].