BCR and B-cell chronic lymphocytic leukemia: The present findings also demonstrate that the autonomous signalling in CLL is not a consequence of a generalized, intrinsic property of the preimmune BcR IG, but rather can also be acquired through distinct processes in IG affinity maturation, for example, class-switch recombination (as in subset no. 4) or the introduction of precise SHMs (as in subset no. 2 IgMs) that can be specific for each CLL case or subset thereof.