TNFRSF10B and neoplasm: The 8p21.3 risk variants rs2241261 and rs2889 (used as proxy for rs2241260, P=1.6 × 10−9, r2=0.61 with rs2241261 in CEU; Supplementary Data 1) are located 0.9 and 1.7 kb respectively from TNFRSF10B, a tumour suppressor gene encoding a mediator of apoptosis signalling29.