TREX1 and breast carcinoma: In human breast carcinoma cells, MDA-MB-231 Trex1 expression began to increase only at 15 Gy and reached levels sufficient to markedly decrease cytosolic dsDNA at 18 Gy (Fig. 8a), while in human breast carcinoma cells 4175TR a slight increase in Trex1 expression was already detectable at 10 Gy and reached levels sufficient to markedly decrease cytosolic dsDNA at 12 Gy (Fig. 8b).