To determine if responsiveness to IFNβ by TSA cells was required for the therapeutic effect of 8GyX3+anti-CTLA4, IFNAR1 expression was abrogated in TSA cells expressing an inducible shRNA targeting Ifnar1 (TSAshIfnar1) by feeding mice with doxycycline before tumour irradiation (Fig. 2a,b). This evidence concerns the gene IFNAR1 and neoplasm.