In vivo, knockdown of cGAS in TSA cells before the treatment with 8GyX3+anti-CTLA4 abrogated the radiation-induced recruitment and activation of CD8α+ TIDCs (Supplementary Fig. 5a,b), the priming of tumour-specific CD8+ T cells in tumour-draining lymph nodes and spleen (Fig. 5b,c), and the infiltration of abscopal tumour by CD8+ T cells (Fig. 5d). The gene discussed is CGAS; the disease is neoplasm.