Consistent with the latter finding, the examination of glioma patient-based mRNA expression databases first suggested that aberrant NF-κB activation was preferentially associated with GBM cases with a mesenchymal phenotype, rather than GBM subtypes with more neural features (many of which are defined as having a proneural phenotype) [52,53,54]. The gene discussed is NFKB1; the disease is central nervous system cancer.