NFKB1 and cancer: Consistent with the complex nature of NF-κB activation in response to a variety of stimuli, aberrant NF-κB activity in cancer may ensue as a result of numerous events, including mutation or deregulated expression of genes encoding the NF-κB proteins or, more frequently, the perturbation of the mechanisms controlling the activation of NF-κB dimers [21,22,23,24,25].