In summary, we believe that DLEU1 promotes the pathogenesis and development of epithelial ovarian cancer through its interaction with miR‐490‐3p, thereby altering the expression of the miR‐490‐3p target genes, that is, CDK1, CCND1 and SMARCD1, as well as the expression of MMP2, Bcl‐xLand P70S6K. This evidence concerns the gene RPS6KB1 and ovarian carcinoma.