Much of our understanding of the molecular and cellular features of HGPS has come from the analyses of patient dermal fibroblasts or overexpression of Progerin in genotypically normal human cells (Eriksson et al., 2003; Goldman et al., 2004; Scaffidi & Misteli, 2006; Shumaker et al., 2006). Here, LMNA is linked to Hutchinson-Gilford progeria syndrome.