Based on the negative prognostic role of epidermal growth factor receptor (EGFR) in head and neck squamous cell carcinoma [1, 2], Burley et al. from London, UK, developed a PET tracer for imaging EGFR by conjugating the long-lived isotope 89Zr to an Affibody specific for EGFR via the chelator deferoxamine (89Zr-DFO-AffiEGFR:03115) [3]. The gene discussed is EGFR; the disease is head and neck squamous cell carcinoma.