SAA concentration was significantly higher in subjects with T2DM, compared to controls in serum (30 mg/L (17, 68) versus 15 mg/L (7, 36); p = 0.002), HDL2 (1.0 mg/L (0.6, 2.2) versus 0.4 mg/L (0.2, 0.7); p < 0.001), and HDL3 (13 mg/L (8, 29) versus 6 mg/L (3, 13); p < 0.001) (Table 2). This evidence concerns the gene SAA1 and type 2 diabetes mellitus.