Adjustment for physical factors including BMI, elevated blood pressure, diabetes, blood lipids, and C-reactive protein attenuated the association between ICAM-1 and cognitive test scores, mostly to non-significance, evidenced based on the 3 degree of freedom test; we consider this attenuation to be explanatory, in that these physical factors could be on a pathway between ICAM-1 and cognitive test scores. This evidence concerns the gene CRP and diabetes mellitus.