Epidemiological studies including the Honolulu–Asia Study (24), Rotterdam Study (25, 26), EURODEM (27), and Kungsholmen Project (28) report several vascular risk factors such as high blood pressure, diabetes mellitus, atherosclerosis, apolipoprotein E, heart failure, and recent strokes being associated with dementia, which causes cerebral hypoperfusion (24, 26, 28). The gene discussed is APOE; the disease is atherosclerosis.