IGF1 and Insulin resistance: In the present study, we have decided to analyse the metabolic profile (insulin resistance and lipids) in two untreated groups of GHD patients: (1) with lower (worse) IGF-I bioavailability and (2) with higher (better) IGF-I bioavailability, and we have tried to evaluate the additional role of nutritional state, as well as ghrelin, leptin, adiponectin, and resistin on metabolic profile in these groups.