Decreased angiotensin II (Ang II) receptor binding in the substantia nigra and striatum in the brain of patients with PD has been described, and evidence is available that neurons are able to synthesize angiotensinogen in ventrolateral medulla (13), thalamus, hypothalamus, and brain stem (13–15) and that Ang II is found in supraoptic nuclei and hypothalamus (16). Here, AGT is linked to Parkinson disease.