NLRP3 and Sepsis: Melatonin has been shown to restore the mitochondrial production of ATP in septic mice (López et al., 2006a), block the septic response by disrupting connection of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) with nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) in mice (El Frargy et al., 2015) and improve survival in a zymosan A-induced rat model of sepsis/shock (Reynolds et al., 2003).