NLRP3 and subarachnoid hemorrhage: Furthermore, NLRP3 inflammasome activation was showed to be associated with the upregulation of apoptotic signaling pathway in various inflammatory diseases (Volt et al., 2016) and melatonin attenuated subarachnoid hemorrhage-induced BBB damage via attenuating the expressions of NLRP3 (Dong et al., 2016).