Recent studies show that the type I interferonopathy associated with SLE and AGS is potentially cGAS-STING dependent, and that the aberrant IFN-I response can be suppressed by the loss of DNA sensor or STING in cells or animals expressing mutated Trex1 or Samhd [180, 186]. The gene discussed is TREX1; the disease is systemic lupus erythematosus.