As shown in Fig. 6a–c, a significant increase in the sizes and weights of the tumors was observed in the HK2-overexpressing group compared to the control group, whereas the overexpression of miR-125a can significantly decrease tumor volume, suggesting that HK2 overexpression can attenuate the suppressive effect of miR-125a on tumor growth. The gene discussed is HK2; the disease is neoplasm.