Recent studies indicate that breast cancer cell-secreted miR-122 suppresses glucose uptake by niche cells and facilitates metastasis by targeting pyruvate kinase32, and miR-155/miR-143 cascade controls glycolysis by regulating HK2 expression in breast cancer cells14, demonstrating that miRNA is of functional importance in regulating glucose metabolism in cancer cells. The gene discussed is HK2; the disease is cancer.