These genes were reported to be methylated in gastric cancer (RORA, GDNF, PRDM5 and MLF1, ref. 12) or in H. pylori-infected gastric mucosa (MYOD1, SLC16A12, IGF2, MIR124A1 and CDH1, ref. 13). This evidence concerns the gene PRDM5 and gastric cancer.