We have previously reported that CXCR7 (independent of binding its ligand, stromal cell-derived factor 1α [SDF-1α]) interacts with the epidermal growth factor receptor (EGFR), leading to increased EGF-stimulated EGFR phosphorylation (particularly at tyrosine 1110 [Y1110]), enhanced downstream mitogenic signaling as well as tumor cell proliferation and survival13, 16. Here, ACKR3 is linked to neoplasm.