As expected, SLE (100, 200 and 300 μg/mL) treatment for 48 h apparently suppressed the phosphorylation of STAT3 (Tyr705) and Src (Tyr 416), but did not affect total STAT3 and total Src expressions, in both A375 and B16F10 cells (Fig. 5A and B). Here, SRC is linked to systemic lupus erythematosus.