Compared to control, the serum protein level of several inflammatory molecules including HMGB-1, ICAM-1 and VCAM in MMD patients was strikingly increased by 92.32% [57.000 (34.000, 154.000) vs. 27.000 (13.500, 61.000), P < 0.05], 31.66% [38.070 (31.750, 42.760) vs. 28.080 (21.280, 34.905), P < 0.01] and 51.5% [158.135 (130.560, 211.360) vs. 103.975 (85.435, 135.810), P < 0.001], respectively. This evidence concerns the gene HMGB1 and multiminicore myopathy.