Similarly, Th17-related IL-17, TNF-α, IL-6 and IL-23 were significantly higher than control by 57.94% [130.655 (99.710, 150.030) vs. 78.565 (74.070, 85.455), P < 0.001], 7.33% [16.680 (15.870, 17.620) vs. 15.970 (14.500, 16.835), P < 0.05], 92.52% [8.420 (7.130, 11.770) vs. 5.285 (2.855, 7.265), P < 0.001] and 39.47% [10.925 (8.200, 15.800) vs. 8.185 (6.950, 9.575), P < 0.01] in MMD patients, respectively (Supplement Fig. 1). The gene discussed is TNF; the disease is multiminicore myopathy.