Furthermore, the pathway enrichment analysis of putative target genes of the DEMs yielded similar signaling cascades (highly significantly enriched) including cancer, immune, cell cycle, apoptosis, p53 signaling, Wnt signaling, MAPK signaling and other relevant pathways which further complement the functional findings of the DEMs using IPA-based methods, suggesting a potential role of miRNA-mediated regulation during TAA treatment (Tables S4 and S5). The gene discussed is TP53; the disease is cancer.