Finally, by comparing Pltp−/− mice and wild-type mice with naturally high PLTP activity, it was further demonstrated that endogenous PLTP combines both LPS transfer properties (as demonstrated here not only in endotoxic shock, but also in a polymicrobial model of sepsis) and bacteriostatic properties (as shown in vitro on cultured E. coli and in vivo after CLP surgery). This evidence concerns the gene PLTP and Sepsis.