HAUS5 and Joubert syndrome: Our results demonstrate the first down stream targets of ZNF131 in mammals, which include genes associated with Joubert Syndrome and primary cilium function and HAUS5. It is conceivable that ZNF131 evolved as an adaption to promote or maintain Augmin/HAUS complex activity during key times in development via transcriptional regulation of HAUS5. We were able to show that ZNF131 affects steady-state levels of RNAP at that HAUS5 promoter, consistent with transcriptional regulation.