IGFBP3 and neoplasm: 2017). Based on our findings, this molecule warrants further exploration. CAV1 expression displayed the largest absolute correlation with tumor stage, followed by VIM, IGFBP3, and ITGA1. CAV1 has not been described in the context of EMT in ccRCC, but it is over‐expressed in hepatocellular carcinoma and promotes cancer cell invasion via inducing EMT (Gai et al. 2014). Accordingly, increased expression of CAV1 can predict a poor prognosis of patients with ccRCC (Steffens et al. 2011).