CYBB and androgen insensitivity syndrome: Messenger RNA (mRNA) expression of NOX2, the enzyme responsible for extracellular release of ROS and amplification of microglial pro-inflammatory response [38], was significantly increased at 6 h (p < 0.01) and remained elevated 3 days post-LPS injection (p < 0.05), returning to control levels prior to AIS recovery (Fig. 2i).