To evaluate if the atypical SORL1 immunoreactivity patterns were exclusively found in PED.25 family members, we analyzed 10 additional sporadic AD cases and 10 controls, and found that in total five out of 14 sporadic AD cases and two of the 14 controls showed some immunoreactivity in glial cells, similar to the pattern in the two PED.25 cases. Here, SORL1 is linked to Alzheimer disease.