Mitochondrial deficits have been previously described in CMT-causing mutations in genes that are directly linked to mitochondrial function, such as Mitofusin 2 (MFN-2) and GDAP1, which are involved in mitochondrial fusion and fission and are known to play a central role in regulating mitochondrial function (52,53). This evidence concerns the gene MFN2 and Charcot-Marie-Tooth disease.