Mutations in Hsp27 are responsible for approximately 4% of CMT2 cases in Italy (10), whereas a more recent study of 17,000 CMT patients established the overall prevalence of Hsp27 mutations at 0.3% among CMT cases and thus, approximately 1% of CMT2 (11). The gene discussed is HSPB1; the disease is Charcot-Marie-Tooth disease type 2.