Vesicle trafficking and axonal transport abnormalities have been a major focus of research in hereditary peripheral neuropathies, due to the high number of genes involved in either the axonal transport machinery, such as mutations affecting molecular motors, or important elements of the cytoskeleton, such as NF-L and NEFH (38–41), or genes directly responsible for vesicle biogenesis, such as Rab7 (42,43). Here, NEFH is linked to peripheral neuropathy.