Since an additional iron overload is associated with worse outcomes in other liver diseases [15], we further explored the iron parameters in the total cohort and found elevations in the majority of the 109 patients with untreated AIH-1 (hyperferritinemia in 65%, elevated SI in 58% and elevated transferrin saturation in 48% of patients) (S1 Table). The gene discussed is TF; the disease is liver disorder.