Examples of human genetic variation and susceptibility to specific infectious syndromes include susceptibility to severe sepsis in Chinese Han subjects with the rs1800629 variant of the TNF gene [1], genetic variants of TRAF6 and increased susceptibility to sepsis-induced acute lung injury [2], variants in β2-adrenocepter and an increased susceptibility to bacterial meningitis [3], Toll-like receptor variants associated with both infectious and autoimmune diseases [4], and IL17A variation in association with susceptibility to Gram-positive infection and severe sepsis [5]. The gene discussed is TNF; the disease is Sepsis.