In recent years, mounting evidence has demonstrated that lncRNAs are important regulatory molecules in diverse biological and pathological processes, such as lncRNA UCA1 increases the cisplatin resistance of bladder cancer cells[38], lncRNA MALAT1 enhances the metastasis of osteosarcoma cells[39], LncRNA-ROR induces epithelial-to-mesenchymal transition of breast cancer cells[40] and lncRNA CCAT1 promotes the proliferation and migration of hepatocellular carcinoma cells[8]. The gene discussed is LINC-ROR; the disease is osteosarcoma.