SOD1 and amyotrophic lateral sclerosis: Secondly, the genes in the classifiers are significantly enriched for those differentially expressed in microdissected neurons from pre-symptomatic SOD1-mutant mice versus control mice[7–9] (HGD p-Values = 1.18E-06, 2.75E-05, and 6.78E-05 for Classifiers 1–3, respectively), and ALS-related genes in the ALSoD database on 01/06/2015[34] (HGD p-Values = 5.18E-3, 8.77E-3, and 0.03, for Classifiers 1–3, respectively).