MAPT and early-onset autosomal dominant Alzheimer disease: More recently, we found that 71% of these Basque GRN carriers also carry a rare variant in the microtubule-associated protein tau gene (MAPT) in exon 7 (p.A152T) [6], which has been linked to risk for both FTD-spectrum disorders and clinical Alzheimer’s disease (AD) [7,8].