WEE1 and cancer: Overexpression and activating mutations of GPCRs are linked to tumor growth, angiogenesis and metastasis,34, 35 and targeting mutated or deregulated GPCRs are promising in experimental cancer therapy.36, 37 The GRKs constitute a group of protein kinases (seven members in mammals) that specifically recognize and phosphorylate agonist-activated GPCRs.