The hypoxic environment of a tumor leads to stabilization of the HIF1α, which stimulated glycolysis through induction of glucose transporters, hexokinase II (HKII) and lactate dehydrogenase A, and inhibited mitochondrial respiration by pyruvate dehydrogenase kinase 1 (PDK1).15 Glycolysis promoted by HIF1α provided abundant precursors for fatty acid synthesis. The gene discussed is PDK1; the disease is neoplasm.