TP53 and cancer: To date, several FASN inhibitors have shown antitumor activity including cerulenin, C75, orlistat, C93, GSK 837149A and natural plant-derived polyphenols.27 Cerulenin, a natural compound isolated from Cephalosporium caerulens, and its derivative C75 reacted with FASN to inhibit its activity, inducing cancer cell apoptosis by p53 accumulation, induction of ER stress and so on.30, 31 When FASN was knocked down, the cell growth of colon cancer cells and their nucleus translocation of β-cantenin were inhibited.