Especially in the responder tumor overexpressed transcripts include the growth factors TGFB1 (log 2fc=−2.07) and TGFB1/1 (log 2fc=−3.27) themselves, as well as their direct pathway targets SMAD3 (log 2fc=−2.44) and SMAD7 (log 2fc=−3.86). This evidence concerns the gene SMAD3 and neoplasm.