Thus, upregulation of the NIMA kinase pathway may be the upstream signal for the observed induction of the immune response-related pathways 'CLEC7A/inflammasome pathway' and 'interleukin-19 (IL-19), -20, -22 and -24' that indicate enhanced innate defense and tissue repair processes in the non-responder tumor. The gene discussed is IL19; the disease is neoplasm.