In HCCs as in other cancers such as ovarian cancer, TGFBR3 may function as a cancer suppressor,12 and in pancreatic cancer loss of TGFBR3 expression promoted cancer progression.22 In a pancreatic cancer model of the EMT, TGFBR3 suppresses the associated increased motility and invasiveness. This evidence concerns the gene TGFBR3 and familial pancreatic carcinoma.