KRAS and familial pancreatic carcinoma: Beside antigen-pulses dendritic cells, various strategies are developed such as: DNA vaccine with the VEGF-receptor DNA, peptide vaccination (Gastrine17-DT vaccination, mutated peptides of Kras), CRS-207 (attenuated form of Listeria monocytogenes that has been genetically-modified to express mesothelin), TELOVAC (vaccination trial using a 16-amino acid telomerase peptide - GV1001) and GVAX (mix of allogenic human pancreatic cancer cells expressing and secretin GM-CSF) [38,94,95,96,97,98,99,100].