In contrast, STAT3 inhibitors that are designated based on more common strategies for inhibiting STAT3 transcriptional activity such as JAK inhibitors, STAT3 dimerization domain inhibitors, STAT3-DNA binding blockers, and antisense oligonucleotide inhibitor of STAT3 have been in various developmental stages or in clinical trials for cancer treatment (reviewed nicely in references [8,9,10,109]). Here, STAT3 is linked to cancer.