Confocal microscopy experiments indicated that CypA co-localized with the endogenous RIG-I and MAVS in 293T cells after infection with SeV (Figure 4H), which are consistent with the results of Figure 4F,G, indicating that RIG-I and MAVS were the target proteins of CypA to augment RIG-I-mediated type I IFN production. The gene discussed is MAVS; the disease is infection.