Moreover, CypA functions as an important host factor that regulates the replication of a number of viruses, including human immunodeficiency virus type I (HIV-1), hepatitis C virus (HCV), human papillomavirus (HPV), IAV, rotavirus (RV), enterovirus-71 (EV71) virus, and infectious bursal disease virus (IBDV), which expands the role of CypA in virus infection (Bienkowska-Haba et al., 2009; Chatterji et al., 2009; Towers et al., 2003; He et al., 2012; Liu et al., 2012b, 2009; Qing et al., 2014; Wang et al., 2015; Xu et al., 2010). The gene discussed is PPIA; the disease is viral infectious disease.