Aberrant pre-mRNA alternative splicing is thought to be an important factor in generating the suite of abnormalities observed in patients with the neurodevelopmental disorder RTT and implicates MeCP2 in splicing mechanisms (Young et al., 2005; Bienvenu and Chelly, 2006; Maunakea et al., 2013; Li et al., 2016; Cheng et al., 2017). This evidence concerns the gene MECP2 and Rett syndrome.