These four constructs as well as an empty vector control were individually stably expressed in three very different human cancer cell lines, namely the BRAFV600E mutation-positive melanoma cell line UACC-62 (Fig. 2a–c), the EGFR mutation-positive NSCLC cell line PC9 (Fig. 2d–f), and the PDGFR-amplified NSCLC cell line NCIH1703 (Fig. 2g–i). The gene discussed is EGFR; the disease is melanoma.