ccRCC has a relatively low mutation burden relative to other solid tumours14 but does have characteristic large deletions and gains of chromosomes 3p, 14q and 5q, respectively, as well as more focal gains and losses of 8q24 (harbouring MYC) and 9p21 (harbouring CDKN2A), respectively5, 12, 15. The gene discussed is MYC; the disease is nonpapillary renal cell carcinoma.