However, MDA-MB-231 TNBC cells, which possess normal phosphatase and tensin homologue function (a tumour suppressor gene that inactivates AKT) are resistant to temsirolimus, whereas MDA-MB-468 TNBC cells (with loss of phosphatase and tensin homologue function) were 8,000-fold more sensitive to this drug37. The gene discussed is AKT1; the disease is neoplasm.